Disease: Dementia
Type of study: Interventional trial
Coordinating investigator: Ragnhild Eide Skogseth & Kristoffer Haugarvoll
Study directors: Ragnhild Eide Skogseth & Kristoffer Haugarvoll
Background: Dementia, including Alzheimer’s disease (AD) and Dementia with Lewy bodies (DLB), is the most common group of neurodegenerative disorders. Dementia is a heterogeneous group of disorders, where a mixture of several types of pathologies is often present in individual patients.
The central hypothesis in this project is that converging molecular pathways exist across subtypes of dementia, but also that there are underlying subtypes that may not be fully reflected in the current classification system of dementia.
STRAT-COG is a study to better understand mixt pathologies in dementia and to identify sub-groups of disease that reflect underlying biology. The group proposes to identify biological overlap and disease subtypes, based on a transdisciplinary approach integrating cognitive testing, clinical investigations, neuroimaging and molecular biomarkers. Thus, this approach will enable us to reclassify and stratify dementia according to underlying biological patterns. The study also includes a brain donation program.
Primary objective: To establish a cohort with multidimensional data that can be orderly integrated into the complex clinical and biological spectrum of dementia, and to stratify it into subclasses with homogeneous biology and prognosis. This knowledge will then be used to develop diagnostic and prognostic biomarkers and identify novel therapeutic targets. Design: Cohort study with biannual follow-up.
Status: The study was initiated in 2022. By November 2024 166 individuals suffering from dementia and 47 control individuals have been included. A brain bank has been established as part of the study.
Participating centres
- Haraldsplass Deaconess Hospital, Bergen
- Haukeland University Hospital, Bergen
Funding
- The Research Council of Norway, Neuro-SysMed
- The Regional Health Authority of Western Norway
- Haraldsplass Deaconess Hospital
- Haukeland University Hospital
- University of Bergen