GEMRIC - The Global ECT-MRI Research Collaboration

Brain changes induced by electroconvulsive therapy (ECT) – understanding treatment mechanisms and predictors of clinical response.

Logo GEMRIC. Graphics

The Global ECT-MRI Research Collaboration was founded at a collaborative meeting in Bergen in June 2015, and is coordinated by Leif Oltedal. The principal idea behind this initiative is that collaboration and mega-analyses of combined study data will lead to new discoveries. In the first phase, GEMRIC will include up to 550 subjects including patients (clinical and neuroimaging data before and after ECT) and controls (healthy or patients with depression that receive other treatments).  However, with our latest study “The GEMRIC study for determining the mechanisms of action of electroconvulsive therapy”, the collaboration will be extended and we aim at increasing the sample size to 2000 subjects.

Mohn Medical Imaging Visualization Centre



Leif Oltedal, Hauke Bartsch, Ole Johan Evjenth Sørhaug, Ute Kessler, Christopher Abbott, Annemieke Dols, Max L Stek, Lars Ersland, Louise Emsell, Philip van Eijndhoven, Miklos Argyelan,Indira Tendolkar, Pia Nordanskog, Paul Hamilton, Martin Balslev Jorgensen, Iris E Sommer,Sophie M Heringa, Bogdan Draganski, Ronny Redlich, Udo Dannlowski, Harald Kugel, Filip Bouckaert, Pascal Sienaert, Amit Anand, Randall Espinoza, Katherine L Narr, Dominic Holland, Anders M Dale, Ketil J Oedegaard NeuroImage: Clinical 14 (2017) 422–432

The Global ECT-MRI Research Collaboration (GEMRIC) Establishing a multi-site investigation.pdf 


Leif Oltedal, Katherine L. Narr, Christopher Abbott, Amit Anand, Miklos Argyelan, Hauke Bartsch, Udo Dannlowski, Annemieke Dols, Philip van Eijndhoven, Louise Emsell, Vera Jane Erchinger, Randall Espinoza, Tim Hahn, Lars G. Hanson, Gerhard Hellemann, Martin Balslev Jorgensen, Ute Kessler, Mardien L. Oudega, Olaf B. Paulson, Ronny Redlich, Pascal Sienaert, Max L. Stek, Indira Tendolkar, Mathieu Vandenbulcke, Ketil J. Oedegaard, Anders M. Dale “Volume of the Human Hippocampus and Clinical Response Following Electroconvulsive Therapy,” Biological Psychiatry, vol. 84, iss. 8, pp. 574-581, 2018.

Volume of the Human Hippocampus and Clinical Response Following ECT.pdf


O. T. Ousdal, M. Argyelan, K. L. Narr, C. Abbott, B. Wade, M. Vandenbulcke, M. Urretavizcaya, I. Tendolkar, A. Takamiya, M. L. Stek, and others, “Brain changes induced by Electroconvulsive Therapy are broadly distributed,” Biological Psychiatry, 2019.

Brain changes Induced by electroconvulsive therapy Are Broadly Distributed.pdf

B. S. Wade, G. Hellemann, R. T. Espinoza, R. P. Woods, S. H. Joshi, R. Redlich, A. Jørgensen, C. C. Abbott, K. J. Ødegaard, S. M. McClintock, L. Oltedal, and K. Narr, “Depressive Symptom Dimensions in Treatment-Resistant Major Depression and Their Modulation With Electroconvulsive Therapy,” The journal of ECT, 2019. doi:10.1097/YCT.0000000000000623

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