Variables in the registry

​​Person Identification/Demographics

• Name and identification number
• Birthdate
• Gender
• Informed consent

Diagnosis

• Year and month of onset
• Year and month of diagnosis
• Disease course
• Onset symptom
• Number of relapses or progressive symptom at diagnosis
• MRI at diagnosis
• Evoked potentials at diagnosis
• CSF-analyses at diagnosis

Disease modifying treatment and follow-up

• Ongoing treatment
• Any previous medication and reason for changes
• Any reason for no treatment
• Any side effects
• Neutralizing antibody analysis during interferon beta and natalizumab treatment
• JC-virus screening during natalizumab treatment

Disease activity and clinical scoring

• Number of relapses
• MRI examination – and recording of any new lesions
• Expanded Disability Status Scale (EDSS)
• Multiple Sclerosis Functional Composite (MSFC)
• Symbol Digit Modalities Test (SDMT)
• Symptom checklist – the presence of any symptoms and any treatment of those

Patients reported outcome measures (Not yet included in electronic registration system)

• Fatigue Severity Scale (FSS)
• Multiple Sclerosis Impact Scale (MSIS-29)
• Health-related quality of life assessment by the EuroQol-5D (EQ-5D) (16)

Other variables

• Co-morbidity
• Concomitant medication
• Family members with MS
• Previous Epstein-Barr virus infection
• Serum vitamin D levels
• Smoking habits
• Vital signs