Publikasjoner om diarésykdom

Diaresykdom er meget vanlig i tropiske strøk og er den nest vanligste årsak til småbarnsdød i verden. Det forekommer også ofte hos reisende til tropiske områder. 

Ved tropesenteret drives forskning på årsaker og interaksjoner mellom mikrober ved småbarnsdiare i Etiopia og Tanzania. I Etiopia gjør vi studier av point-of-care diagnostikk av Cryptosporidium og langvarig diare.

I flere år har vi fulgt en kohort av personer som fikk langvarige mageplager og tretthet etter Giardia-infeksjon etter utbrudd i Bergen, og spesielt fokus har vært på immunresponser mot Giardia hos mennesker.

Sammen med St.Olavs hospital og Ullevål samles inn materiale for å analysere genetisk variasjon av Giardia som er refraktær mot metronidazol behandling.

I samarbeid med Senter for internasjonal helse, UiB gjøres også challenge- og immunologiske studier av diare med enterotoxicogen E. coli (ETEC) som er den vanligste årsaken til turistdiare.

Publikasjoner

Radunovic M, Klotz C, Saghaug CS, Brattbakk HR, Aebischer T, Langeland N, Hanevik K. Genetic variation in potential Giardia vaccine candidates cyst wall protein 2 and α1-giardin. Parasitol Res. 2017 Jun 3. doi: 10.1007/s00436-017-5516-9.

Moyo SJ, Kommedal Ø, Blomberg B, Hanevik K, Gjerde Tellevik M, Maselle SY, Langeland N. Comprehensive analysis of prevalence, epidemiological and clinical characteristics of mono- infections and co-infections in diarrhoeal diseases in children in Tanzania. Am J Epidemiol. 2017 May 24. doi: 10.1093/aje/kwx173.

Hanevik K. Giardia lamblia – pathogen or commensal? Clin Infect Dis. 2016 Sep 15;63(6):798-9. doi: 10.1093/cid/ciw392. PubMed PMID:
27313270

Wensaas KA, Hanevik K, Hausken T, Eide GE, Langeland N, Mørch K, Rortveit G. Postinfectious and sporadic functional gastrointestinal disorders have different prevalences and rates of overlap: results from a controlled cohort study 3 years after acute giardiasis. Neurogastroenterol Motil. 2016 May 18. doi: 10.1111/nmo.12856. PMID: 27189227

Litleskare S, Wensaas KA, Eide GE, Hanevik K, Kahrs GE, Langeland N, Rortveit G. Perceived food intolerance and irritable bowel syndrome in a population 3 years after a giardiasis-outbreak: a historical cohort study. BMC Gastroenterol. 2015 Nov 19;15:164. doi: 10.1186/s12876-015-0393-0. PMID: 26585714 

Tellevik MG, Moyo SJ, Blomberg B, Hjøllo T, Maselle SY, Langeland N, Hanevik K. Prevalence of Cryptosporidium parvum/hominis, Entamoeba histolytica and Giardia lamblia among Young Children with and without Diarrhea in Dar es Salaam, Tanzania. PLoS Negl Trop Dis. 2015 Oct 9;9(10):e0004125.

Robertson LJ, Tysnes KR, Hanevik K, Langeland N, Mørch K, Hausken T, Nygård K. Dogs as the source of Giardia in Bergen in 2004 – barking up the wrong tree?  Tidsskr Nor Laegeforen. 2015 Oct 20;135(19):1718-20. doi: 10.4045/tidsskr.15.0883. PMID: 26486664

Tellevik MG, Moyo SJ, Blomberg B, Hjøllo T, Maselle SY, Langeland N, Hanevik K. Prevalence of Cryptosporidium parvum/hominis, Entamoeba histolytica and Giardia lamblia among Young Children with and without Diarrhea in Dar es Salaam, Tanzania. PLoS Negl Trop Dis. 2015 Oct 9;9(10):e0004125. doi: 10.1371/journal.pntd.0004125. PMID: 26452235

Saghaug CS, Sørnes S, Peirasmaki D, Svärd S, Langeland N, Hanevik K. Human Memory CD4+ T Cell Immune Responses against Giardia lamblia. Clin Vaccine Immunol. 2015 Sep 16;23(1):11-8. doi: 10.1128/CVI.00419-15. PMID: 26376930

Hanevik K, Bakken R, Brattbakk HR, Saghaug CS, Langeland N. Whole genome sequencing of clinical isolates of Giardia lamblia. Clin Microbiol Infect. 2015 Feb;21(2):192.e1-3. doi: 10.1016/j.cmi.2014.08.014. PMID:25596782

Persson R, Wensaas KA, Hanevik K, Eide GE, Langeland N, Rortveit G. The relationship between irritable bowel syndrome, functional dyspepsia, chronic fatigue and overactive bladder syndrome: a controlled study 6 years after acute gastrointestinal infection. BMC Gastroenterol. 2015 Jun 10;15:66. doi: 10.1186/s12876-015-0296-0.PMID: 26058591

Johansen OH, Hanevik K, Thrana F, Carlson A, Stachurska-Hagen T, Skaare D, Robertson LJ. Symptomatic and asymptomatic secondary transmission of Cryptosporidium parvum following two related outbreaks in schoolchildren. Epidemiol Infect. 2014 Sep 30:1-8.

Moyo SJ, Hanevik K, Blomberg B, Kommedal O, Nordbø SA, Maselle S, Langeland N. Prevalence and molecular characterisation of human adenovirus in diarrhoeic children in Tanzania; a case control study. BMC Infect Dis. 2014 Dec 12;14:666. doi: 10.1186/s12879-014-0666-1.

Moyo S, Hanevik K, Blomberg B, Kommedal O, Vainio K, Maselle S, Langeland N. Genetic diversity of norovirus in hospitalised diarrhoeic children and asymptomatic controls in Dar es Salaam, Tanzania. Infect Genet Evol. 2014 Aug;26:340-7. doi: 10.1016/j.meegid.2014.06.013. Epub 2014 Jun 21.

Moyo SJ, Blomberg B, Hanevik K, Kommedal O, Vainio K, Maselle SY, Langeland N. Genetic diversity of circulating rotavirus strains in Tanzania prior to the introduction of vaccination. PLoS One. 2014 May 20;9(5):e97562. doi: 10.1371/journal.pone.0097562. eCollection 2014

Skrede S, Steinsland H, Sommerfelt H, Aase A, Brandtzaeg P, Langeland N, Cox RJ, Sævik M, Wallevik M, Skutlaberg DH, Tellevik MG, Sack DA, Nataro JP, Guttormsen AB. Experimental infection of healthy volunteers with enterotoxigenic Escherichia coli wild-type strain TW10598 in a hospital ward . BMC Infect Dis. 2014 Sep 4;14(1):482. doi: 10.1186/1471-2334-14-482.

Hanevik K, Alvsvåg JO, Sund KK. En ung kvinne med langvarig diare og slapphet. Tidsskr Nor Legeforen 2014; 134:189 – 92

Escobedo AA, Hanevik K, Almirall P, Cimerman S, Alfonso M. Management of chronic Giardia infection. Expert Rev Anti Infect Ther. 2014 Sep;12(9):1143-57. doi: 10.1586/14787210.2014.942283.

Hanevik K, Wensaas KA, Rortveit G, Eide GE, Mørch K, Langeland N. Irritable Bowel Syndrome and Chronic Fatigue 6 Years After Giardia Infection: A Controlled Prospective Cohort Study. Clin Infect Dis. 2014 Aug 12. pii: ciu629.

Stadelmann B, Hanevik K, Andersson MK, Bruserud O, Svärd SG. The role of arginine and arginine-metabolizing enzymes during Giardia - host cell interactions in vitro. BMC Microbiol 2013;13():256. Epub 2013 nov 14 PMID: 24228819

Mørch K, Hanevik K, Rivenes AC, Bødtker JE, Næss H, Stubhaug B, Wensaas KA, Rortveit G, Eide GE, Hausken T and Langeland N. Chronic fatigue syndrome 5 years after giardiasis: differential diagnoses, characteristics and natural course. BMC Gastroenterology 2013, 13:28. Epub 2013 febr 06

Hanevik K, Kristoffersen EK, Sørnes S, Mørch K, Næss H, Rivenes AC, Bødtker JE, Hausken T, Langeland N. Immunophenotyping in post-giardiasis functional gastrointestinal disease and chronic fatigue syndrome. BMC Infect Dis 2012 Oct;12(1):258. Epub 2012 okt 14
PMID: 23061432

Hunskar GS, Langeland N, Wensaas KA, Hanevik K, Eide GE, Mørch K, Rortveit G. The impact of atopic disease on the risk of post-infectious fatigue and irritable bowel syndrome 3 years after Giardia infection. A historic cohort study.  Scand J Gastroenterol 2012 Sep;8-9(47):956-61. Epub 2012 jul 2  PMID: 22746290

Wensaas KA, Langeland N, Hanevik K, Mørch K, Eide GE, Rortveit G.
Irritable bowel syndrome and chronic fatigue 3 years after acute giardiasis: historic cohort study. Gut 2012 Feb;61(2):214-9. Epub 2011 sep 12  PMID: 21911849

Hanevik K, Kristoffersen E, Svard S, Bruserud Ø, Ringqvist E, Sørnes S, Langeland N. Human cellular immune response against Giardia lamblia 5 years after acute giardiasis. J Infect Dis 2011 Dec;204(11):1779-86. Epub 2011 okt 11 PMID: 21990423

Hanevik K, Dizdar V, Langeland N, Eide G E, Hausken T. Tolerability and effect of mesalazine in postinfectious irritable bowel syndrome.
Aliment Pharmacol Ther 2011 Jul;34(2):259-60. PMID: 21679211

Robertson LJ, Hanevik K, Escobedo AA, Mørch K, Langeland N. Giardiasis-why do the symptoms sometimes never stop?  Trends Parasitol 2010 Feb;26(2):75-82. Epub 2010 jan 6 PMID: 20056486

Wensaas KA, Langeland N, Rortveit G. Post-infectious gastrointestinal symptoms after acute Giardiasis. A 1-year follow-up in general practice. Fam Pract 2010 Jun;27(3):255-9. Epub 2010 mar 22 PMID: 20308244 

Mellingen KM, Midtun A, Hanevik K, Eide GE, Søbstad Ø, Langeland N. Post epidemic giardiasis and gastrointestinal symptoms among preschool children in Bergen, Norway. A cross-sectional study. BMC Public Health 2010;10():163. Epub 2010 mar 26 PMID: 20346102

Escobedo AA, Almirall P, Robertson LJ, Franco RMB, Hanevik K, Mørch K, Cimerman S. Giardiasis: the ever-present threat of a neglected disease.
Infect Disord Drug Targets 2010 Oct;10(5):329-48.  PMID: 20701575

Wensaas KA, Langeland N, Rortveit G. Prevalence of recurring symptoms after infection with Giardia lamblia in a non-endemic area. Scand J Prim Health Care 2009;27(1):12-7. PMID: 19085428
 
Hanevik K, Dizdar V, Langeland N, Hausken T. Development of functional gastrointestinal disorders after Giardia lamblia infection. BMC Gastroenterol 2009;9():27. Epub 2009 apr 21 PMID: 19383162

Mørch K, Hanevik K, Rortveit G, Wensaas KA, Eide GE, Hausken T, Langeland N. Severity of Giardia infection associated with post-infectious fatigue and abdominal symptoms two years after. BMC Infect Dis 2009;9():206. Epub 2009 des 15 PMID: 20003489

Mørch K, Hanevik K, Rortveit G, Wensaas KA, Langeland N. High rate of fatigue and abdominal symptoms two years after an outbreak of giardiasis. Transactions of Royal Society of Tropical Medicine and Hygiene (2009) 103, 530-532.

Mørch K, Hanevik K, Robertson LJ, Strand EA, Langeland N.Treatment-ladder and genetic characterisation of parasites in refractory giardiasis after an outbreak in Norway.  J Infect. 2008 Apr;56(4):268-73. 

Hanevik K, Mørch K, Eide GE, Langeland N, Hausken T. Effects of albendazole/metronidazole or tetracycline/folate treatments on persisting symptoms after Giardia infection: a randomized open clinical trial. Scand J Infect Dis. 2008;40(6-7):517-22

Strand EA, Robertson LJ,Hanevik K, Alvsvåg JO,Mørch K, Langeland N. Sensitivity of a Giardia antigen test in persistent giardiasis following an extensive outbreak. Clin Microbiol Infect. 2008 Nov;14(11):1069-71.

Hanevik K, Mørch K, Eide GE, Langeland N, Hausken T. Effects of albendazole/metronidazole or tetracycline/folate treatments on persisting symptoms after Giardia infection: a randomised open clinical trial. Scand J Infect Dis. 2008, Vol. 40, No. 6-7 , Pages 517-522

Robertson LJ, Forberg T, Hermansen L, Gjerde BK and Langeland N. Molecular characterisation of giardia isolates from clinical infection following a waterborne outbreak. J Infect. 2007 Jul;55(1):79-88. Epub 2007 Mar 26.

Robertson LJ, Forberg T, Hermansen L,  Gjerde B, Langeland N. Demographics of giardia infections in Bergen, Norway, subsequent to a waterborne outbreak. Scand J Infect Dis. 2007 Jul 31;:1-4

Hanevik K, Hausken T, Morken MH, Strand EA, Mørch K, Coll P, Helgeland L, Langeland N. Persisting symptoms and duodenal inflammation related to Giardia duodenalis infections. Journal of infection. Epub Oct 2007.

Nygard K, Schimmer B, Sobstad O, Walde A, Tveit I, Langeland N, Hausken T, Aavitsland P. A large community outbreak of waterborne giardiasis-delayed detection in a non-endemic urban area. BMC Public Health. 2006 May 25;6:141.

Robertson LJ, Forberg T, Hermansen L, Gjerde BK, Alvsvåg JO, Langeland N. Cryptosporidium parvum infections in Bergen, Norway, during an extensive outbreak of waterborne giardiasis in autumn and winter 2004. App Environ Microbiol. 2006;72(3):2218-20

Robertson LJ, Hermansen L, Gjerde BK, Strand E, Alvsvåg JO, Langeland N.  Application of genotyping during an extensive outbreak of waterborne giardiasis in Bergen, Norway, during autumn and winter 2004. Appl.Environ.Microbiol. 2006; 72:2212-7.