Søvnlengde og søvnrelaterte symptomer over to generasjoner - resultater fra to samfunnsbaserte studier

Forskere fra Sverige, Norge, Danmark, Estland og Island har i denne studien undersøkt sammenhengen mellom søvnrelaterte symptomer og søvnlengde hos 5855 foreldre (gjennomsnittsalder 54.år) og deres 5955 voksne barn (gjennomsnittsalder 30,2 år) med data fra to store samfunnsbaserte studier. I studiene ble det brukt identiske spørreskjemaer om insomnisymptomer, snorking, nattlig svette, nattlig refluks, søvnlengde og dagtrøtthet. Alle søvnvariabler unntatt nattlig svetting var vanligere hos barna hvis foreldrene hadde rapportert det samme symptomet.

Sleep time and sleep-related symptoms across two generations - results of the community-based RHINE and RHINESSA studies

Eva Lindberg, Christer Janson, Ane Johannessen, Cecilie Svanes, Francisco Gomez Real, Andrei Malinovschi, Karl A Franklin, Mathias Holm, Vivi Schlünssen, Nils Oskar Jogi, Thorarinn Gislason, Bryndis Benediktsdóttir

Studien er publisert i Sleep Medicine

Study objectives: To analyze the association between sleep-related symptoms and sleep length in parents and their children in relation to other risk factors in both generations.
Method: The participants were parents (n = 5,855, age 54.3 ± 6.5 years, 45.2% men) who participated in the community-based Respiratory Health in Northern Europe (RHINE) study and one random member of their adult offspring (n = 5,855, age 30.2 ± 7.7 years, 41.5% men) who participated in the Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) study. Both generations responded to identical questionnaires on sleep symptoms, including difficulty initiating sleep (DIS), difficulty maintaining sleep (DMS), early morning awakening (EMA), snoring, nocturnal sweating, nocturnal gastroesophageal reflux (nGER), sleep time and excessive daytime sleepiness (EDS). Insomnia was defined as either, or both, DIS and DMS in combination with EDS.
Results: All sleep variables except nocturnal sweating were more common in offspring whose parents had reported the same symptom. After adjusting for age, gender, BMI, smoking, physical activity, education, center and parents' total number of children, there were independent associations between sleep symptoms in parents and offspring for DIS (adj. OR, 95% CI: 1.52, 1.20-1.93), DMS (1.34, 1.15-1.56), snoring (1.45, 1.15,1.83), nGER (1.65, 1.15-2.37), insomnia (1.39, 1.13-1.73), short sleep time (<6 h/night) (2.51, 1.72-3.68) and EDS (1.48, 1.26,1.72). There were no independent relationships between symptoms in parents and offspring for EMA, nocturnal sweating or long sleep time (>9 h/night).
Conclusion: The familiar aggregation of many sleep disturbances was not explained by investigated lifestyle and environmental factors. This supports a heritable factor in sleep problems.