Søvnkvalitet hos pasienter med avansert kreftsykdom

Forskere fra NTNU, Trondheim Universitetssykehus, St. Olavs Hospital, Universitetet i Aberdeen, Universitetet i Oslo og Universitetssykehuset «Carl Gustav Carus» i Dresden har i denne internasjonale tverrsnittstudien (N=604) undersøkt søvnkvalitet hos pasienter med avansert kreft som er under behandling med WHO trinn III (opioider ved sterke smerter).

Gunnhild Jakobsen, Morten Engstrøm, Peter Fayers, Marianne J Hjermstad, Stein Kaasa, Marianne Kloke, Rainer Sabatowski og Pal Klepstad

Sleep quality with WHO Step III opioid use for cancer pain 
Studien er publisert i BMJ Supportive & Palliative Care


Objective: Sleep is often disturbed in patients with advanced cancer. There is limited knowledge about sleep in patients with cancer treated with strong opioids. This study examines sleep quality in patients with advanced cancer who are treated with a WHO Step III opioid for pain.

Methods: An international, multicentre, cross-sectional study with 604 adult patients with cancer pain using WHO Step III opioids. Sleep quality was assessed by the Pittsburgh Sleep Quality Index (PSQI) global score (range; 0–21; score >5 indicates poor sleep). PSQI includes sleep quality, sleep latency, sleep duration, sleep efficiency, sleep disturbances, use of sleep medications and daytime dysfunction. Pain and quality of life were assessed by Brief Pain Inventory and European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core30.

Results: The median age was 62 years, 42% were female, mean Karnofsky performance score (KPS) was 62.5 (±14.2) and mean oral daily morphine equivalent dose was 303 mg/24 hours (±543.8 mg). The mean PSQI global score was 8.8 (±4.2) (range 0–20). Seventy-eight per cent were poor sleepers. All PSQI components were affected, and 44% reported trouble sleeping caused by pain. In the multiple regression model, predictors of PSQI global scores were pain intensity, emotional function, constipation, financial difficulties and KPS (adjusted R2=0.21).

Conclusion: The majority (78%) of these patients with cancer treated with Step III opioids experienced poor sleep quality. Pain intensity, emotional function, constipation, financial difficulties and KPS predicted poor PSQI global scores. The clinical implication is that healthcare personnel should routinely assess and treat sleep disturbance in patients with advanced cancer disease.