Sammenhengen mellom ulike somatiske sykdommer og alvorlighetsgraden av obstruktiv søvnapné

Forskere fra Universitetet i Bergen og Haukeland Universitetssykehus har i denne studien undersøkt forekomsten av hjerteinfarkt, angina pectoris, slag, hypertensjon, diabetes mellitus, kronisk obstruktiv lungesykdom, astma, fedme og deres assosiasjon til obstruktiv søvnapné og dens alvorlighetsgrad (n= 1887). Resultatene viser en høyere forekomst av hjerteinfarkt, angina pectoris, hypertensjon, diabetes mellitus og fedme hos personer med mer alvorlig grad av obstruktiv søvnapné.

Prevalence of sevral somatic diseases depends on the presence and severity of obstructive sleep apnea

Ragnhild L. Tveit, Sverre Lehmann og Bjørn Bjorvatn

Studien er publisert i Plus One


Study objectives


The objective was to investigate the prevalence of heart attack, angina pectoris, stroke,
hypertension, diabetes mellitus, chronic obstructive pulmonary disease, asthma and obesity
in relation to the presence and severity of obstructive sleep apnea.


Methods: The sample consisted of 1887 patients, with mean age of 48.6 years (range 16±83 years),referred to a university hospital on suspicion of obstructive sleep apnea. The patients filled out a questionnaire asking whether they were previously diagnosed with the comorbidities in interest. Obstructive sleep apnea was diagnosed and categorized based on a standard respiratory polygraphic sleep study using a type 3 portable monitor. The patients' weight, height and blood pressure were measured during the consultations.


Results: In total, 37.9% were categorized as not having obstructive sleep apnea (Apnea-hypopnea index <5), 29.6% mild obstructive sleep apnea (Apnea-hypopnea index 5±14.9), 17.3% moderate obstructive sleep apnea (Apnea-hypopnea index 15±29.9), and 15.2% severe
obstructive sleep apnea (Apnea-hypopnea index _30). The prevalence of heart attack,
angina pectoris, hypertension, measured systolic blood pressure _140 mmHg, measured
diastolic blood pressure _90 mmHg, diabetes mellitus and obesity (body mass index_30)
were higher with greater obstructive sleep apnea severity. Logistic and linear regression
analyses showed that these comorbidities were positively associated with obstructive sleep
apnea severity. This was not the case for stroke, chronic obstructive pulmonary disease and
asthma. After adjustment for sex, age, alcohol and smoking in the logistic regression analyses,
hypertension, measured systolic blood pressure _140 mmHg, measured diastolic
blood pressure _90 mmHg and obesity remained positively associated with obstructive
sleep apnea severity.

Conclusions: A higher prevalence of heart attack, angina pectoris, hypertension, diabetes mellitus, and obesity was seen with greater obstructive sleep apnea severity. Obesity and hypertension, conditions easy to clinically assess, appear as the most central comorbidities with greater obstructive sleep apnea severity.