Insomni kan øke risiko for astma

I denne prospektive studien har forskere fra Norges teknisk-naturvitenskapelige universitet undersøkt hvorvidt det kan være sammenheng mellom insomni og risiko for å utvikle astma. Data er hentet fra Helseundersøkelsen i Nord-Trøndelag med over 17 900 deltagere. Symptomer på insomni og astma ble målt ved baseline og ved oppfølging 11 år senere. Kronisk insomni var assosiert med en økt risiko for å utvikle astma, og det ble funnet en positiv dose-respons sammenheng – flere insomni symptomer var assosiert med høyere risiko for å utvikle astma.

 

Studien er publisert i European Respiratory Journal


Prospective study of insomnia and incident asthma in adults: the HUNT study


Ben Brumpton, Xiao-Mei Mai, Arnulf Langhammer, Lars Erik Laugsand, Imre Janszky, Linn Beate Strand


Insomnia is highly prevalent among asthmatics; however, few studies have investigated insomnia symptoms and asthma development. We aimed to investigate the association between insomnia and the risk of incident asthma in a population-based cohort. Among 17 927 participants free from asthma at baseline we calculated odds ratios and 95% confidence intervals for the risk of incident asthma among those with insomnia compared to those without. Participants reported sleep initiation problems, sleep maintenance problems and nonrestorative sleep. Chronic insomnia was defined as those reporting one or more insomnia symptom at baseline and 10 years earlier. Incident asthma was defined by questions on asthma at baseline and follow-up (average 11 years). The prevalence of sleep initiation problems, sleep maintenance problems and nonrestorative sleep were 1%, 1% and 5%, respectively. The multi-adjusted odds ratios were 1.18 (95% CI 0.97-1.44), 1.30 (95% CI 1.03-1.64) and 1.70 (95% CI 1.37-2.11) for people with one, two and three insomnia symptoms, respectively, compared with people without symptoms (p<0.01 for trend). The risk of developing asthma in those with chronic insomnia was three times higher (adjusted OR 3.16, 95% CI 1.37-6.40) than those without. Insomnia symptoms were associated with increased risk of incident asthma in this study.