Effekt av søvnmangel på epileptiske anfall

I denne prospektive overkryssningsstudien ble det undersøkt om søvnmangel kan være en utløsende faktor for epileptiske anfall. Totalt ble 152 voksne personer intervjuet ved akutt innleggelse for epileptisk anfall og ved oppfølging. Studien er utført av forskere fra St. Olavs hospital og Norges teknisk-naturvitenskapelige universitet.

​Studien er publisert i Epilepsy Research  

The impact of sleep loss on the facilitation of seizures: A prospective case-crossover study 

Christian Samsonsen, Trond Sand, Geir Bråthen, Grethe Helde, Eylert Brodtkorb

PURPOSE: The relationship between sleep and seizures is intricate. The aim of this study was to assess whether sleep loss is an independent seizure precipitant in a clinical setting.

METHODS: In this prospective, observational cross-over study, 179 consecutive hospital admissions for epileptic seizures were included. A semi-structured interview regarding several seizure precipitants was performed. The sleep pattern prior to the seizure, as well as alcohol, caffeine and drug use, were recorded. The interview was repeated by telephone covering the same weekday at a time when there had been no recent seizure. The Hospital Anxiety and Depression Scale (HADS) and a visual analogue scale for perceived stress were applied at admission. Student's t-test, Fisher exact test and ANOVA were used for statistical analyses.

RESULTS: Complete data for analysis were retrieved in 144 patients. The sleep-time during the 24h prior to the seizure was lower (7.3h) compared to follow-up (8.3h; p<0.0005). Caffeine consumption and use of relevant non antiepileptic drugs (AED) were not different. HADS and stress scores at admission did not correlate with sleep-time difference. In ANOVA, controlled for alcohol consumption and AED use, the sleep-time difference remained significant (p=0.008). The interaction with alcohol intake was high, but the sleep-time difference remained highly significant also for the non- and low-consumption (≤2 units per day) subgroup (n=121, 7.50h vs 8.42h, p=0.001).

CONCLUSION: Epileptic seizures are often precipitated by a combination of various clinical factors, but sleep loss stands out as an independent seizure trigger.