Papers and abstracts
Published papers and abstracts from ongoing research within RHINESSA and other closely related publications by the RHINESSA group.


Papers 2019

Lau MYZ, Dharmage SC, Burgess JA, Win AK, Lowe AJ, Lodge CJ, Perret J, Hui J, Thomas PS, Giles G, Thompson BR, Abramson MJ, Walters EH, Matheson MC; investigators of the TAHS and MACS. Early-life exposure to sibling modifies the relationship between CD14 polymorphisms and allergic sensitization. Clin Exp Allergy. 2019 Mar. Read more here.

Timm S, Schlünssen V, Benediktsdottir B, Bertelsen RJ, Bråbäck L, Holm M, Jogi R, Malinovschi A, Svanes C, Frydenberg M. Offspring reports on parental place of upbringing: Is it valid? Epidemiology. 2019 doi: 10.1097/EDE.0000000000000988. [Epub ahead of print] Read the full text here.

Timm S, Frydenberg M, Abramson MJ, Bertelsen RJ, Bråbäck L, Benediktsdottir B,Gislason T, Holm M, Janson C, Jogi R, Johannessen A, Kim JL, Malinovschi A, Mishra G, Moratalla J, Sigsgaard T, Svanes C, Schlünssen V. Asthma and selective migration from farming environments in a three-generation cohort study. Eur J Epidemiol. 2019 Feb 7. doi: 10.1007/s10654-019-00491-9. [Epub ahead of print]. Read the full text here.

Pape K, Svanes C, Malinovschi A, Benediktsdottir B, Lodge C, Janson C, Moratalla J, Sánchez-Ramos JL, Bråbäck L, Holm M, Jögi R, Bertelsen RJ, Sigsgaard T, Johannessen A, Schlünssen V. Agreement of offspring-reported parental smoking status: the RHINESSA generation study. BMC Public Health. 2019 Jan 21;19(1):94. Read the full text here.

Papers 2018

Pérez Barrionuevo AM, Gómez Real F, Igland J, Johannessen A, Omenaas E, Franklin KA, Pérez Barrionuevo L, Åstrøm AN, Bertelsen RJ and Svanes C. Periodontal health status and lung function in two Norwegian cohorts. PLoS One. 2018 Jan 19;13(1). Read the full text here.

Kuiper IN, Svanes C, Benediktsdottir B, Bertelsen RJ, Bråbäck L, Dharmage SC, Holm M, Janson C, Jögi R, Malinovschi A, Matheson M, Moratalla JM, Real FG, Sánchez-Ramos JL, Schlünssen V, Timm S, Johannessen A. Agreement in reporting of asthma by parents or offspring - the RHINESSA generation study. BMC Pulm Med. 2018 Jul 27;18(1):122. Read the full text here.

Hammer B, Wagner C, Divac Rankov A, Reuter S, Bartel S, Hylkema MN, Krüger A, Svanes C, Krauss-Etschmann S. In utero exposure to cigarette smoke and effects across generations: A conference of animals on asthma. Clin Exp Allergy. 2018 Nov;48(11):1378-1390. Read the full text here.

 Janson C, Johannessen A, Franklin K, Svanes C, Schiöler L, Malinovschi A, Gislason T, Benediktsdottir B, Schlünssen V, Jõgi R, Jarvis D, Lindberg E. Change in the prevalence asthma, rhinitis and respiratory symptom over a 20 year period: associations to year of birth, life style and sleep related symptoms. BMC Pulm Med. 2018 Sep 12;18(1):152. Read the full text here.

Marcon A, Pesce G, Calciano L, Bellisario V, Dharmage SC, Garcia-Aymerich J, Gislasson T, Heinrich J, Holm M, Janson C, Jarvis D, Leynaert B, Matheson MC, Pirina P, Svanes C, Villani S, Zuberbier T, Minelli C, Accordini S; Ageing Lungs In European Cohorts study. Trends in smoking initiation in Europe over 40 years: A retrospective cohort study. PLoS One. 2018 Aug 22;13(8):e0201881. Read the full text here.

Mørkve Knudsen T, Rezwan FI, Jiang Y, Karmaus W, Svanes C, Holloway JW.Transgenerational and intergenerational epigenetic inheritance in allergic diseases. J Allergy Clin Immunol. 2018 Sep;142(3):765-772. Read the full text here.

Gómez Real F, Burgess JA, Villani S, Dratva J, Heinrich J, Janson C, Jarvis D, Koplin J, Leynaert B, Lodge C, Lærum BN, Matheson MC, Norbäck D, Omenaas ER, Skulstad SM, Sunyer J, Dharmage SC, Svanes C. Maternal age at delivery, lung function and asthma in offspring: a population-based survey. Eur Respir J. 2018 Jun 7;51(6). pii: 1601611. Read the full text here.

Reference: Erbas B, Knudsen TM, Janson C, Nilsen RM, Accordini S, Benediktdottir B, Dratva J, Heinrich J, Jarvis D, Leynaert B, Matheson MC, Norbäck D, Real FG, Raherison-Semjen C, Villani S, Dharmage SC, Svanes C. Critical age windows in the impact of lifetime smoking exposure on respiratory symptoms and disease among ever smokers. Environ Res. 2018 Mar 6;164:241-247. Read the full text here.

Accordini S, Calciano L, Johannessen A, Portas L, Benediktsdóttir B, Bertelsen RJ, Bråbäck L, Carsin AE, Dharmage SC, Dratva J, Forsberg B, Gomez Real F, Heinrich J, Holloway JW, Holm M, Janson C, Jögi R, Leynaert B, Malinovschi A, Marcon A, Martínez-Moratalla Rovira J, Raherison C, Sánchez-Ramos JL, Schlünssen V, Bono R, Corsico AG, Demoly P, Dorado Arenas S, Nowak D, Pin I, Weyler J, Jarvis D, Svanes C; Ageing Lungs in European Cohorts (ALEC) Study. A three-generation study on the association of tobacco smoking with asthma. Int J Epidemiol. 2018 Aug 1;47(4):1106-1117. Read the full text here. 

Lønnebotn M, Svanes C, Igland J, Franklin KA, Accordini S, Benediktsdóttir B, Bentouhami H, Blanco JAG, Bono R, Corsico A, Demoly P, Dharmage S, Dorado Arenas S, Garcia J, Heinrich J, Holm M, Janson C, Jarvis D, Leynaert B, Martinez-Moratalla J, Nowak D, Pin I, Raherison-Semjen C, Sánchez-Ramos JL, Schlünssen V, Skulstad SM, Dratva J, Gómez Real F. Body silhouettes as a tool to reflect obesity in the past. PLoS One. 2018 Apr 25;13(4):e0195697. Read the full text here.

Svanes Ø, Bertelsen RJ, Lygre SH, Carsin AE, Antó JM, Forsberg B, García-García JM, Gullón JA, Heinrich J, Holm M, Kogevinas M, Urrutia I, Leynaert B, Moratalla JM, Le Moual N, Lytras T, Norbäck D, Nowak D, Olivieri M, Pin I, Probst-Hensch N, Schlünssen V, Sigsgaard T, Skorge TD, Villani S, Jarvis D, Zock JP, Svanes C. Cleaning at Home and at Work in Relation to Lung Function Decline and Airway Obstruction. Am J Respir Crit Care Med. 2018 May 1;197(9):1157-1163. Read the full text here. 

Jõgi NO and Svanes C, Siiak SP, Logan E, Holloway JW, Igland J, Johannessen A, Levin M, Real FG, Schlunssen V, Horsnell WGC, Bertelsen RJ. Zoonotic helminth exposure and risk of allergic diseases: A study of two generations in Norway. Clin Exp Allergy. 2018 Jan;48(1):66-77. Read the full text here. 

Lønnebotn M, Natvig GK, Benediktsdóttir B, Burgess JA, Holm M, Jogi R, Lindberg E, Macsali F, Schlünssen V, Skulstad SM, Franklin KA, Vanky E, Real FG. “Polycystic ovary syndrome and body mass index as related to hypertensive disorders in pregnancy”. Pregnancy Hypertension.  2018 Jan;11:32-37. Read the full text here.

Papers 2017

Skulstad SM, Igland J, Johannessen A, Bertelsen RJ, Lønnebotn M, Omenaas ER, Svanes C and Real FG. Validation of maternal reported pregnancy and birth characteristics against the Medical Birth Registry of Norway. PLoS One. 2017 Aug 4;12(8). Read the full text here.

Svanes C , Koplin J, Skulstad SM, Johannessen A, Bertelsen RJ, Benediktsdottir B, Bråbäck L, Elie Carsin A, Dharmage S, Dratva J, Forsberg B, Gislason T, Heinrich J, Holm M, Janson C, Jarvis D, Jögi R, Krauss-Etschmann S, Lindberg E, Macsali F, Malinovschi A, Modig L, Norbäck D, Omenaas E, Waatevik Saure E, Sigsgaard T, Skorge TD, Svanes Ø, Torén K, Torres C, Schlünssen V, Gomez Real F. Father's environment before conception and asthma risk in his children: a multi-generation analysis of the Respiratory Health In Northern Europe. Int J Epidemiol. 2017 Feb 1;46(1). Read the full text here.

Pereira-Vega A, Sánchez-Ramos JL, Alvarado-Gómez F, Maldonado-Pérez JA, Svanes C , Gómez Real F."Risk factors of Premenstrual Asthma. A systematic review and meta-analysis". Expert Rev Respir Med. 2017 Jan. Read the full text here.

Russell MA, Janson C, Real FG, Johannessen A, Waatevik MJ, Benediktsdóttir B, Holm M, Lindberg E, Schlünssen V, Raza W, Svanes C* and Dharmage S* shared last authorship. “Physical activity and asthma: a longitudinal and multi-country study”. Journal of Asthma. 2017 Feb. Read the full text here.

Papers 2016

Dratva D, Zemp E, Dharmage SC, Accordini S, Burdet L, Gislason T, Heinrich J, Janson C, Jaravis D, deMarco R, Norbäck D, Pons M, Real FG, Sunyer J, Villani S, Probst-Hensch N, Svanes C. Early Life Origins of Lung Ageing: Early Life Exposures and Lung Function Decline in Adulthood in Two European Cohorts Aged 28-73 Years. PLoS One. 2016 Jan 26;11(1):e0145127. Read the full text here.

Dratva J, Bertelsen R, Janson C, Johannessen A, Benediktsdottir B, Bråbäck L, Forsberg B, Gislason T, Jarvis D, Jögi R, Lindberg E, Omenaas E, Schlünssen V, Skorge TD, Sigsgaard T, Torén K, Waatevik M, Wielander G, Dharmage SC, Svanes C* and Real FG*. *shared last author. Validation of self-reported figural drawing scales against anthropometric measurements in adults. Public Health Nutr. 2016 Feb 16:1-8. Read the full text here.

Real FG, L. Perez Barrionuevo, K. Franklin, E. Lindberg, R. J. Bertelsen, B. Benediktsdottir, B. Forsberg, T. Gislason, R. Jogi, A. Johannessen, E. Omenaas, E. Saure, V. Schlunssen, T. D. Skorge, K. Toren, A. Perez Saavedra, O. Svanes, A. N. Astrom, C. Janson and C. Svanes (2016). "The Association of Gum Bleeding with Respiratory Health in a Population Based Study from Northern Europe." PLoS One 11(1): e0147518. Read the full text here.

André F. S. Amaral, David P. Strachan, Francisco Gómez Real, Peter G. J. Burney, Deborah L. Jarvis (2016) “Lower lung function associates with cessation of menstruation: UK Biobank data”. Eur Resp J. 2016 Sep 22. pii: ERJ-00412-2016. doi: 10.1183/13993003.00412-2016. Read the full text here.

Campbell B, Raherison C, Lodge C, Lowe A, Gislason T, Heinrich J, Sunyer J, Real FG , Norbäck D, Matheson M , Wjst M, Dratva J, De Marco R, Jarvis D , Janson C, Leynaert B, Svanes C, Dharmage S. “Growing up on a farm as related to adult lung function and allergic phenotypes: An international population based study”. Thorax 2016. Sep 26. Read the full text here.

Rovira, Nerea Muniozguren Agirre, Isabelle Pin, Nicole Probst-Hensch, Luca Puggini, Chantal Raherison, José Luis Sánchez-Ramos, Vivi Schlünssen, Jordi Sunyer, Cecilie Svanes, Steinar Hustad, Bénédicte Leynaert* and Francisco Gómez Real. “Menopause is associated with accelerated lung function decline in the longitudinal European Community Respiratory Health Survey”. Am J Resp Med Crit Care. 2016 Dec. Read the full text here.

Papers 2015

Aanerud M, Carsin AE, Sunyer J, Dratva J, Gislason T, Jarvis D, deMarco R, Raherison C, Wjst M, Dharmage SC, Svanes C. Interaction between asthma and smoking increases the risk of adult airway obstruction. Eur Respir J. 2015 Mar;45(3):635-43. doi: 10.1183/09031936.00055514. Epub 2014 Nov 27. PubMed PMID: 25431272. Read more here.

Svanes Ø, Skorge TD, Johannessen A, Bertelsen RJ, Bråtveit M, Forsberg B, Gislason T, Holm M, Janson C, Jögi R, Macsali F, Norbäck D, Omenaas ER, Real FG, Schlünssen V, Sigsgaard T, Wieslander G, Zock JP, Aasen T, Dratva J, Svanes C. Respiratory Health in Cleaners in Northern Europe: Is Susceptibility Established in Early Life? PLoS One. 2015 Jul 13. Read more here.

Timm S, Frydenberg M, Janson C, Campbell B, Forsberg B, Gislason T, Holm M, Jogi R, Omenaas E, Sigsgaard T, Svanes C* and Schlünssen V*. *shared last author. The Urban-Rural Gradient In Asthma: A Population-Based Study in Northern Europe. Int J Environ Res Public Health. 2015 Dec 30;13(1). Read more here.

Matheson MC, Burgess JA, Lau MYZ, Lowe AJ, Gurrin LC, Hopper JL, Giles GG, Johns DP, Walters EH, Abramson MJ, Real FG and Dharmage SC (2015). “Hormonal contraception increases risk of asthma among obese women”. ERJ Open Res, 2015. Read more here.

Papers 2014

Johannessen A, Verlato G, Benediktsdottir B, Forsberg B, Franklin K, Gislason T, Holm M, Janson C, Jögi R, Lindberg E, Macsali F, Omenaas E, Real FG, Saure EW, Schlünssen V, Sigsgaard T, Skorge TD, Svanes C, Torén K, Waatevik M, Nilsen RM, de Marco R. Longterm follow-up in European respiratory health studies - patterns and implications. BMC Pulm Med. 2014 Apr 16. Read more here.

Papers 2013

Macsali, F., C. Svanes, R. B. Sothern, B. Benediktsdottir, L. Bjorge, J. Dratva, K. A. Franklin, M. Holm, C. Janson, A. Johannessen, E. Lindberg, E. R. Omenaas, V. Schlunssen, E. Zemp and Real FG (2013). "Menstrual cycle and respiratory symptoms in a general Nordic-Baltic population." Am J Respir Crit Care Med 187(4): 366-373. Read more here

Papers 2012

Leynaert, B., J. Sunyer, R. Garcia-Esteban, C. Svanes, D. Jarvis, I. Cerveri, J. Dratva, T. Gislason, J. Heinrich, C. Janson, N. Kuenzli, R. de Marco, E. Omenaas, C. Raherison, Real FG, M. Wjst, E. Zemp, M. Zureik, P. G. Burney, J. M. Anto and F. Neukirch (2012). "Gender differences in prevalence, diagnosis and incidence of allergic and non-allergic asthma: a population-based cohort." Thorax 67(7): 625-631. Read more here

Macsali, F., C. Svanes, L. Bjorge, E. R. Omenaas and Real FG (2012). "Respiratory health in women: from menarche to menopause." Expert Rev Respir Med 6(2): 187-202. Review. Read more here


Papers 2011

Macsali, F., Real FG, E. Plana, J. Sunyer, J. Anto, J. Dratva, C. Janson, D. Jarvis, E. R. Omenaas, E. Zemp, M. Wjst, B. Leynaert and C. Svanes (2011). "Early age at menarche, lung function, and adult asthma." Am J Respir Crit Care Med 183(1): 8-14. Read more here.

Papers 2010

Svanes C, Sunyer J, Plana E, Dharmage S, Heinrich J, Jarvis D, de Marco R, Norbäck D, Raherison C, Villani S, Wjst M, Svanes K, Antó JM. Early life origins of chronic obstructive pulmonary disease. Thorax. 2010 Jan;65(1):14-20. Read more here.

Dratva, J., C. Schindler, I. Curjuric, D. Stolz, F. Macsali, Real FG, E. Zemp and S. Team (2010). "Perimenstrual increase in bronchial hyperreactivity in premenopausal women: results from the population-based SAPALDIA 2 cohort." J Allergy Clin Immunol 125(4): 823-829. Read more here


Abstracts 2017

Three-generation effects of tobacco smoking on lung function within the paternal line. Accordini S et al & Schlünssen V (last author). ERS congress 2017. Link to published abstract

 Oral microbiome and associations with chemical exposure, asthma and lung function. Bertelsen RJ et al & Svanes C (last author). ERS congress 2017. Link to published abstract

 Fathers' overweight and offspring asthma – an intergenerational perspective. Johannessen A et al & Svanes C (last author). Late breaking abstract, ERS congress 2017. Link to published abstract

Epigenome-wide association of father's smoking on offspring DNA methylation. Knudsen TM et al & Svanes C (last author). Late breaking abstract, ERS congress 2017. Link to published abstract

 Validation of self-reported asthma in a generation study. Kuiper IN et al & Johannessen A (last author). ERS congress 2017. Link to published abstract

Mothers' preconception overweight and offspring asthma. Lønnebotn M et al & Svanes and Jarvis (last authors). Late breaking abstract, ERS congress 2017. Link to published abstract

Validation of smoking status reported by parents and their offspring –The RHINESSA generation study. Pape K et al & Schlüssen V (last author). ERS congress 2017. Link to published abstract

Abstracts 2016

Use of oral and nasal tobacco and asthma symptoms in a Nordic population. Bertelsen RJ et al & Svanes C (last author). ERS congress 2016. Link to published abstract

Poor periodontal health is associated with airways obstruction. Perez A et al & Svanes C (last author). ERS congress 2016. Link to published abstract

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